A supplement made from placental ingredients for powerful cellular regeneration and the development of strong and balanced systems.

Placen*

Supreme Placenta Therapy

The placenta connects between the mother’s body and the fetus via the uterus and it facilitates the exchange of gases and nutrients. The placenta is claimed to contain beneficial nutrients (iron, selenium, copper and zinc), amino acids, peptides, vitamins, nucleic acids, growth factors and abundant extracellular matrix (ECM). In plants, the placenta is a specialized region within an ovary to which the ovules are attached to. The placenta of the plant is produced in the heart of their young buds which functions in nourishing the fruit of the plant during its growing stage.

Main Ingredients:
Dermacenta™ Polyenylphosphatidylcholine (PPC)
Available Set:
5 ampoules x 2ml
10 ampoules x 2ml

Cellular Mechanism of MF+ Placen

The extracellular matrix (ECM), present within all tissues and organs, is the largest component in the dermal layer which provides the biochemical network and structural integrity to all surrounding cells. They are comprised of collagens, proteoglycans, glycosaminoglycans, elastin, fibronectin and glycoproteins. However, intrinsic (natural) and extrinsic ageing of the skin caused by lifestyle habits such as UV radiation, air pollution, unbalanced diet, smoking or alcoholic consumption will cause degradation of the ECM components leading to the development of wrinkles, sagging and non-elastic skin. Henceforth, MF+ Placen, extracted from vegetal placenta in its purest and native form containing anti-ageing ingredients are introduced to consumers to maintain youthfulness, radiance, whitening and elasticity of the skin.

MF+ Placen, rich in active Dermacenta™ (scientific code 511573), a proprietary ingredient extracted from the buds of a rare non-GMO (non-genetically modified) soybean plant, originated from France contained nutrients similar to human or animal placenta are available in 2 mL x 5 or 10 vials. They are naturally extracted via cold extraction Cryo-PRO™ proteolytic enzyme extraction technology, does not involve and heating thus maintaining its cellular structural walls and DNA cellular components. They contain many bioactive components, beneficial nutrients designed to modulate the ECM thus maintain skin youthfulness, radiance, elasticity, whitening and most prominently, to prevent anti-aging.

References:
1 Friess, S. (2007). Ingesting the placenta: Is it healthy for new moms? USA Today. Retrieved from http://www.usatoday.com/news/health/2007-07-18-placenta-ingestion_N.htm. 17 October 2016.
2 Young, S. M. & Benyshek. (2010). In search of human placentophagy: A cross-cultural survey of human placenta consumption, disposal practices, and cultural beliefs. Ecology of Food and Nutrition. 49: 467-484.
3 Widgerow, A.D., Fabi, S. G., Palestine, R. F., Rivkin, A., Ortiz, A., Bucay, V.W., Chiu, A., Naga, L., Emer, J. & Chasan, P. E. Extracellular matrix modulation: Optimizing skin care and rejuvenation procedures. Journal of Drugs in Dermatology. 15: 63-71.
4 Riemschneider, R. (2008). Vegetal placenta extracts substitute animal placenta. International Electronic Journal on Dermopharmaceutical Technology and Related Cosmetic Subjects. 1-5.

(Figure 2: Cellular mechanism of MF+ Placen

Activation of Growth Factors and Cytokines by MF+ Placen

The skin is divided into three layers: the epidermal, dermal and the hypodermal layer. Within the skin dermal layer, contains the extracellular matrix (ECM) which provide the structural and integrity network to all cells. Administered MF+ Placen will be absorbed from skin epithelial cells followed
by binding to specific receptors present on the surface of the targeted cells followed by activating various growth factors and cytokines thereby regulating the survival, growth, migration and dierentiation of the cells (Table 1). One example shown here is that MF+ Placen could convey messages to fibroblast cells to produce collagen which give elasticity to the skin to slower down the aging process (Figure 1).

Source:
1 Theocharis, A. D., Skandalis, S. S., Gialeli, C. & Karamanos, N. K. (2016). Extracellular matrix structure. Advanced Drug Delivery Reviews. 97: 4-27.

Figure 1:
Constituents of MF+ Placen

Table 1: MF+ Placen triggers the activation of various types of growth factors and cytokines which promote various functions ranging from growth regulation, cells proliferation, cells migration and cells differentiation.

Classifications Functions
Growth factors
Granulocyte-colony stimulating factor (G-CSF) Regulates cell cycle activation, mediates the proliferation and survival of neutrophil progenitors1
Granulocyte-macrophage colony stimulating factor (GM-CSF) Proliferation of macrophage progenitors2
Epidermal growth factor (EGF) Stimulates wound and skin repair3
Fibroblast growth factor (FGF) Promotes the growth of fibroblast cells, tissue regeneration and wound healing4
Hepatocyte growth factor (HGF) Stimulates the production of liver cells and also renal tubular epithelial cell5
Insulin-like growth factor (IGF) Regulates feto-placental growth throughout gestation, promotes the growth of muscle cells6
Platelet-derived growth factor (PDGF) Promotes cell differentiation, proliferation and survival in different organs7
Transforming growth factor (TGF) Promotes proliferation of epithelial cells and tissue remodelling8
Vascular endothelial growth factor (VEGF) Regulation of angiogenesis, and vascular development9
Cytokines
Interleukin-1 (IL-1) Regulation of the immune system and the production of T, B and NK cells10
Interleukin-2 (IL-2) Regulation of the growth and activity of T cells10
Interleukin-4 (IL-4) Elimination of extracellular pathogens and regulation of antibody production11

References:
1 Whitcomb, B. W., Schisterman, E. F., Luo, X. & Chegini, N. (2009). Maternal serum granulocyte colony-stimulating factor levels and spontaneous preterm birth. Journal of Women’s Health. 18: 73-78.
2 Cukrová, V. & Hrkal, Z. (1987). Purification and characterization of granulocyte-macrophage colony stimulating factor of human placenta. Journal of Chromatography. 413: 242-246.
3 Mitchell, A. C., Briquez, P. S., Hubbell, J. A. & Cochran, J. R. (2016). Engineering growth factors for regenerative medicine applications. Acta Biomaterialia. 30: 1-12.
4 Li, X., Wang, C., Xiao, J., McKeehan, W. L. & Wang, F. (2015). Fibroblast growth factors, old kids on the new block. Seminars in Cell and Developmental Biology. 53: 155-167.
5 Horibe, N., Okamoto, T., Itakura, A., Nakanishi, T., Suzuki, T., Kazeto, S. & Tomoda, Y. (1995). Levels of hepatocyte growth factor in maternal serum and amniotic fluid. American Journal of Obstetrics and Gynecology. 937-942.
6 Fowden, A. L. (2003). The insulin-like growth factors and feto-placental growth. Placenta. 24: 803-812.
Chhabra, A., Lechner, A. J., Ueno, M., Acharya, A., Handel, B. V., Wang, Y., Irula-Arispe, M. L., Tallquist, M. D. and 7Mikkola, H. K. A. Trophoblasts regulate the placental hematopoietic niche through PDGF-B Signaling. Developmental Cell. 22: 651-659.
8 Jones, R. L., Stoikos, C., Findlay, J. K. & Salamonsen, L. A. (2006). TGF-β superfamily expression and actions in the endometrium and placenta. Reproduction. 132: 217-232.
9 Andrae, J., Gallini, R. & Betsholtz, C. (2008). Role of platelet-derived growth factors in physiology and medicine. Genes and Development. 22: 1276-1312.
10 Nikolaos, V., Charalampos, G., Dimitrios, Z. & Nikolaos, V. (2015). The endocrine and paracrine role of placental cytokines, growth factors and peptides. An Obstetrics & Gynaecology International Journal. 14: 33-38.
11 Annunziato, F., Romagnani, C. & Romagnani, S. (2015). The 3 major types of innate and adaptive cell-mediated effector immunity. Journal of Allergy and Clinical Immunology. 135: 626-635.

The Goodness and Benefits

Aesthetics

• Skin whitening
• Improves skin complexion
• Anti-ageing
• Collagen production
• Fine line and wrinkles reduction
• Skin elasticity
• Skin firming
• Skin radiance
• Skin revitalisation
• Skin suppleness

Therapeutics

• Detoxify harmful foreign compounds and carcinogens
• Cellular growth production and rejuvenation
• Correct hormone imbalances
• Enhance immunity
• Hormonal regulation
• Immunomodulatory effects
• Regulation of inflammation
• Strong antioxidant
• Vitality and stamina restoration
• Wound healing activity

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