A supplement made from placental ingredients for powerful cellular regeneration and the development of strong and balanced systems.
The placenta connects between the mother’s body and the foetus via the uterus and it facilitates the exchange of gases and nutrients. The placenta is claimed to contain beneficial nutrients (iron, selenium, copper and zinc), amino acids, peptides, vitamins, nucleic acids, growth factors and abundant extracellular matrix (ECM). Maternal placentophagy, the consumption of placenta has been reported since 1970s in some clients of the midwives and health advocates in the United States and Mexico. The mother was able to replenish nutrients and hormones which were lost after parturition, and placentophagy had helped in improving the mood and lactation, and also accelerate physical recovery. Therefore, encapsulation of the placenta to be taken as supplements was noted in various media as well as in industrialised countries as it contains various nutritional benefits.
Purified Placental ingredients
Promote regeneration and wound healing, possess high antioxidant, anti-inflammatory properties, and immunomodulatory effects.
5 ampoules x 2ml
10 ampoules x 2ml
Cellular Mechanism of MF+ Placen
The skin is divided into three layers: the epidermis, dermis and the subcutaneous layer. Within the skin dermal layer, contains the extracellular matrix (ECM) that provides the structural and integrity network to all cells. Administered MF+ Placen will be absorbed from skin epithelial cells followed by binding to specific receptors present on the surface of the targeted cells followed by regulating the survival, growth, migration and differentiation of the cells. One example shown here is that MF+ Placen could convey messages to fibroblast cells to produce collagen which give elasticity to the skin to slower down the ageing process.
(Figure 2: Cellular mechanism of MF+ Placen
The extracellular matrix (ECM), present within all tissues and organs, is the largest component in the dermal layer that provides the biochemical network and structural integrity to all surrounding cells. It is comprised of collagens, proteoglycans, glycosaminoglycans, elastin, fibronectin and glycoproteins. However, intrinsic (natural) and extrinsic ageing of the skin caused by lifestyle habits such as UV radiation, air pollution, unbalanced diet, smoking or alcoholic consumption can cause degradation of the ECM components leading to the development of wrinkles, sagging and non-elastic skin.
MF+ Placen, extracted from placenta in its purest and native form is available in 2ml x 5 or 10 vials. It contains many bioactive components, beneficial nutrients designed to modulate the ECM, thus maintain skin youthfulness, radiance and elasticity, and most prominently, for anti-ageing. It is prepared via microporosis ultra-filtration sterilisation and cold process extraction technology which can retain the natural nutrients, amino acids, peptides and growth factors of the placenta.
Friess, S. (2007). Ingesting the placenta: Is it healthy for new moms?
USA Today. Retrieved from
http://www.usatoday.com/news/health/2007-07-18-placenta-ingestion_N.htm. 17 October 2016. Devlin, L. (2014).
Why do people eat placentas?
BBC news. Retrieved from
http://www.bbc.com/news/uk-england-27307476. 17 October 2016.
Young, S. M. & Benyshek. (2010). In search of human placentophagy:
A cross-cultural survey of human placenta consumption, disposal practices, and cultural beliefs. Ecology of Food and Nutrition. 49: 467-484.
Widgerow, A.D., Fabi, S. G., Palestine, R. F., Rivkin, A., Ortiz, A., Bucay, V.W., Chiu, A., Naga, L., Emer, J. & Chasan, P. E. Extracellular matrix modulation: Optimizing skin care and rejuvenation procedures. Journal of Drugs in Dermatology. 15: 63-71.
Constituents of MF+ Placen
Table 1: Constituents of placenta
Constituents of the placenta
|Collagen (I, IV, VII, XVII)||Provide tensile strength, cell adhesion regulation, tissue development, cellular migration and chemotaxis||(Choi et al., 2013; Franz et al., 2010 )|
|Elastin||Provide elasticity to the skin and recoils to tissues like a spring undergoing repeated stretch||(Franz et al., 2010 )|
|Laminin||Contributors to the basement membrane and functions in cells attachment and differentiation and tissue survival||(Colognato & Yurchenco, 2000)|
|Trace elements (Cu, Fe, Se, Zn)||Contributes to normal human development and body function||(Pathak & Kapil, 2004; Young et al., 2016)|
|Peptides||Acts as messengers at specifc receptor sites to stimulate fibroblasts production and collagen synthesis||(Lupo & Cole, 2007)|
|Cytokines (IL-1, IL-2, IL-4)||Acts as messengers and regulate innate and acquired immunity||(Gill & Prasad, 2008)|
Granulocyte colony stimulating factor (GCSF)
Epidermal growth factor (EGF)
Fibroblast growth factor (FGF)
Hepatocyte growth factor (HGF)
Insulin-like growth factor (IGF)Platelet-derived growth factor (PDGF)
Transforming growth factor (TGF)
Vascular endothelial growth factor (VEGF)
|Acts as messengers and regulate and stimulate growth, proliferation, migration and differentiation of cells. Contributes wound healing, immunomodulatory, antioxidant, antitumor and anti-inflammatory activities.||Traversa & Sussman, 2001; Chakarborty, & Bhattacharyya, 2012; Park et al., 2010.|
Choi, J. S., Kim, J. D., Yoon, H. S. & Cho, Y. W. (2013). Full- thickness skin wound healing using human placenta-derived extracellular matrix containing bioactive molecules. Tissue Engineering. 19: 329-339.
Frantz, C., Stewart, K. M. & Weaver, V. M. (2010). The extracellular matrix at a glance. Journal of Cell Science. 123: 4195-4200.
Colognato, H. & Yurchenco, P. D. (2000). Form and function: The laminin family of heterotrimers. Developmental Dynamics. 218: 213-234.
Young, S. M., Gryder, L. K., David, W. B., Teng, Y., Gerstenberger, S. & Benyshek, D. C. (2016). Human placenta processed for encapsulation contains modest concentrations of 14 trace minerals and elements. Nutrition Research. 36: 872-878.
Pathak, P. & Kapil, U. (2004). Role of trace elements zinc, copper and magnesium during pregnancy and its outcome. Indian Journal of Pediatrics. 71: 1003-1005.
Gill, H. & Prasad, J. (2008). Probiotics, immunomodulation, and health benefits. Advances in Experimental Medicine and Biology. 606: 423-454.
Lupo, M. P. & Cole, A. L. (2007). Cosmeceutical peptides. Dermatologic Therapy. 20: 343-349.
Traversa, B. & Sussman, G. (2001). The role of growth factors, cytokines and proteases in wound management. Primary Intention. 9(4): 161-167.
Chakarborty, P. D. & Bhattacharyya, D. (2012). Aqueous extract of human placenta as a therapeutic agent. Recent Advances in Research on the human placenta. InTech, Rijeka, Crotia. 77-92.
Park, S. Y., Phark, S., Lee., M., Lim, J. Y. & Sul, D. (2010). Anti-oxidative and anti-inflammatory activities of placenta extracts in benzo[a]pyrene-exposed rats. Placenta. 31(10): 873-879.
The Goodness and Benefits of MF+ Placen
• Skin suppleness
• Skin suppleness
• Fine line and wrinkles reduction
• Skin firming
• Skin radiance
• Skin revitalisation
• Skin elasticity
• Collagen production
• Skin elasticity
• Improves skin complexion
• Regulation of inflammation
• Regulation of inflammation
• Strong antioxidant
• Antitumor activity
• Hormonal regulation
• Immunomodulatory effects
• Vitality and stamina restoration
• Cellular growth production and rejuvenation
• Enhance immunity
• Wound healing activity
• Correct hormone imbalances